New Science Shows Advocare’s Catalyst Extends Life Span.
- Ian & Alison Keber
Latest in scientific research shows that supplementation with BCAA’s increases lifespan in mice. http://www.ncbi.nlm.nih.gov/pubmed/20889128
Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice.
Department of Physiology, Human Physiology Unit, Pavia University, Pavia 27100, Italy.
Recent evidence points to a strong relationship between increased mitochondrial biogenesis and increased survival in eukaryotes. Branched-chain amino acids (BCAAs) have been shown to extend chronological life span in yeast. However, the role of these amino acids in mitochondrial biogenesis and longevity in mammals is unknown. Here, we show that a BCAA-enriched mixture (BCAAem) increased the average life span of mice. BCAAem supplementation increased mitochondrial biogenesis and sirtuin 1 expression in primary cardiac and skeletal myocytes and in cardiac and skeletal muscle, but not in adipose tissue and liver of middle-aged mice, and this was accompanied by enhanced physical endurance. Moreover, the reactive oxygen species (ROS) defense system genes were upregulated, and ROS production was reduced by BCAAem supplementation. All of the BCAAem-mediated effects were strongly attenuated in endothelial nitric oxide synthase null mutant mice. These data reveal an important antiaging role of BCAAs mediated by mitochondrial biogenesis in mammals.
This science is not new to the esteemed Scientific Medical Adisory board at Advocare.
Common dietary sources of BCAAs include egg, cow’s milk, whey proteins, red meat and soy. BCAAs make up 40% of the free amino acids in blood plasma. They constitute roughly 35% of the essential amino acids in food. Dietary requirements for the three BCAAs amount to about 35% of the total requirements of essential amino acids. An adult consuming a typical North American diet ingests about 15-25 g of BCAAs per day. The skeletal muscle, as opposed to the liver, is the principal site for the metabolism of BCAAs. Following a protein-rich meal, BCAAs constitute a disproportionately high fraction of the increase in circulating amino acids. These elevated levels of BCAAs are “sensed” by different tissues such as brain and skeletal muscle, thus equipping them as regulatory signals for a number of cellular processes. BCAAs, in particular L-leucine, regulate protein synthesis and degradation, an effect different from their role as amino acid substrates for protein biosynthesis.
AdvoCare BioCharge®, a component of AdvoCare BioTools™, and CATALYST™ are specifically designed to contain high levels of BCAAs. Catalyst also provides lesser amounts of several supporting amino acids. Other AdvoCare products that contain BCAAs as a component of the proteins in the products include Meal Replacement Shakes, Post-Workout Recovery and Muscle Gain™.
AdvoCare’s CATALYST™ was developed for the 1996 US Olympic Wrestling team so that they would not lose muscle strength and mass while working to make weight.
AdvoCare’s CATALYST™ offers results if you need to lose 1lb or 150lbs.
~~~ Awesome news from champions Ian and Alison.
My own personal testimony is that I have been taking Advocare’s CATALYST™ since January 2007 and have to say it is a tremendous product. It’s true that it’s dubbed “Lipo in a bottle” and “Butt and Gut Be Gone”, I call this product “Nitrous Oxide” for your speed! Add these to your nutrition arsenal and you’ll feel the burst of energy during your workout and racing!
Start enjoying the benefits of BCAA’s today by getting AdvoCare CATALYST™ in your life.